Related Experiment Video
Updated: Jun 10, 2026
Longitudinal Intravital Imaging of Brain Tumor Cell Behavior in Response to an Invasive Surgical Biopsy
Published on: May 3, 2019
Clinical trials in brain tumor surgery
Jason M Hoover1, Susan M Chang, Ian F Parney
1Department of Neurologic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Abstract:
The prognosis for patients diagnosed with primary central nervous system tumors, such as gliomas, remains generally poor. Improved treatment (standard therapies and novel strategies) is needed. Glioma surgery is a key part of standard treatment and has established roles in providing tissue for diagnosis and in tumor debulking. Several techniques to increase safe surgical resection have been investigated. In addition, novel surgical modalities introducing therapeutic agents locally are increasingly common. This article reviews recent glioma surgery clinical trials, focusing on outcome studies, novel surgical techniques, and local therapeutic agent delivery.
Insights
Glioblastoma surgery offers diagnosis and debulking but requires improved outcomes. Recent clinical trials explore novel surgical techniques and local therapies to enhance patient prognosis for primary central nervous system tumors.
Area of Science:
- Neuro-oncology
- Neurosurgery
- Clinical Trials
Background:
- Primary central nervous system tumors, like gliomas, have a poor prognosis.
- Effective treatment strategies, including surgery, are crucial for managing these brain tumors.
- Current surgical roles include diagnosis and tumor debulking, with ongoing research for improvement.
Purpose of the Study:
- To review recent clinical trials in glioma surgery.
- To focus on studies examining surgical outcomes, innovative techniques, and local therapeutic agent delivery.
- To highlight advancements in the surgical management of gliomas.
Main Methods:
- Review of recent clinical trials in glioma surgery.
- Analysis of outcome studies related to surgical interventions.
- Examination of novel surgical techniques and local drug delivery modalities.
Main Results:
- Several techniques have been investigated to improve safe surgical resection in gliomas.
- Novel surgical approaches incorporating local therapeutic agents are becoming more prevalent.
- Clinical trials are actively exploring new avenues for glioma treatment via surgery.
Conclusions:
- Continued research and clinical trials are essential for advancing glioma surgery.
- Novel surgical techniques and local therapies show promise for improving patient outcomes.
- Optimizing surgical management remains a key focus in neuro-oncology.
More Related Videos
11:09Establishing Intracranial Brain Tumor Xenografts With Subsequent Analysis of Tumor Growth and Response to Therapy using Bioluminescence Imaging
Published on: July 13, 2010
11:14Creating Anatomically Accurate and Reproducible Intracranial Xenografts of Human Brain Tumors
Published on: September 24, 2014