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Updated: Jun 10, 2026
05:32
In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines
Published on: May 12, 2023
A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives
Karina C Gornall1, Siritron Samosorn, Bongkot Tanwirat
1School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia.
Chemical Communications (Cambridge, England)
|August 18, 2010
Abstract:
ESI mass spectrometry was used to assess the binding of 13-substituted, 5-nitro-2-phenylindolyl- and 2-naphthalenyl-based berberine derivatives to inter- and intramolecular G-quadruplex DNA molecules. In contrast with the parent berberine, the compounds showed selectivity for quadruplex over duplex DNA and stabilised the quadruplex structure. They represent a new class of quadruplex DNA-selective ligands.
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