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Related Concept Videos

Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
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Viruses with RNA Genomes

RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
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Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

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Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus
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Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus

Published on: July 27, 2021

Noncoding RNPs of viral origin.

Joan Steitz1, Sumit Borah, Demian Cazalla

  • 1Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536-0812, USA. joan.steitz@yale.edu

Cold Spring Harbor Perspectives in Biology
|August 20, 2010
PubMed
Summary
This summary is machine-generated.

Viruses produce diverse noncoding RNAs (ncRNAs) that aid their life cycle and combat host defenses. Identifying these viral ncRNA functions remains challenging but is advancing with new technologies.

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Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses
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Last Updated: Jun 10, 2026

Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus
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Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses
11:48

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses

Published on: April 4, 2019

Area of Science:

  • Virology
  • Molecular Biology
  • RNA Biology

Background:

  • Many viruses produce noncoding RNAs (ncRNAs), similar to host cells.
  • Viral ncRNAs exhibit diverse characteristics, including expression timing, structure, and protein interactions.
  • Viruses likely evolve ncRNAs to enhance their life cycle or overcome host responses.

Purpose of the Study:

  • To explore the diversity and potential functions of viral noncoding RNAs.
  • To highlight the challenges in identifying the roles of viral ncRNAs.
  • To emphasize the impact of recent technological advancements on this research area.

Main Methods:

  • Comparative analysis of viral and host ncRNA characteristics.
  • Review of existing literature on viral ncRNA identification and function.
  • Discussion of emerging technologies for ncRNA research.

Main Results:

  • Viral ncRNAs are diverse and likely selected for functional advantages.
  • Significant challenges persist in elucidating the specific functions of viral ncRNAs.
  • Progress in understanding host ncRNAs and new technical tools are expected to accelerate discovery.

Conclusions:

  • Viral ncRNAs play a crucial role in viral pathogenesis and host-virus interactions.
  • Further research is needed to fully understand the functional landscape of viral ncRNAs.
  • Advancements in RNA biology and technology are key to unlocking the secrets of viral ncRNAs.