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Updated: Jun 9, 2026

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase (G6PI)-Induced RA Mice
Published on: January 31, 2020
The hunt for iNKT cell antigens: alpha-galactosidase-deficient mice to the rescue?
Luc Van Kaer1, Sebastian Joyce
1Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. luc.van.kaer@vanderbilt.edu
Abstract:
The endogenous lipids that control the functions of invariant natural killer T (iNKT) cells remain enigmatic. In this issue of Immunity, Darmoise et al. (2010) report that lysosomal alpha-galactosidase A destroys self-antigens recognized by iNKT cells.
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