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Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: Jun 9, 2026

The Bovine Lung in Biomedical Research: Visually Guided Bronchoscopy, Intrabronchial Inoculation and In Vivo Sampling Techniques
09:01

The Bovine Lung in Biomedical Research: Visually Guided Bronchoscopy, Intrabronchial Inoculation and In Vivo Sampling Techniques

Published on: July 3, 2014

Animal models.

Ellen A Walker1

  • 1Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, Pennsylvania 19140, USA. eawalker@temple.edu

Advances in Experimental Medicine and Biology
|August 27, 2010
PubMed
Summary
This summary is machine-generated.

Chemotherapy can impair learning and memory. Preclinical animal models are crucial for understanding these cognitive deficits and developing therapies to mitigate them.

Related Experiment Videos

Last Updated: Jun 9, 2026

The Bovine Lung in Biomedical Research: Visually Guided Bronchoscopy, Intrabronchial Inoculation and In Vivo Sampling Techniques
09:01

The Bovine Lung in Biomedical Research: Visually Guided Bronchoscopy, Intrabronchial Inoculation and In Vivo Sampling Techniques

Published on: July 3, 2014

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Clinical studies indicate chemotherapy agents can negatively impact human cognitive functions.
  • Preclinical animal models are essential for studying chemotherapy-induced cognitive deficits and their neural underpinnings.

Purpose of the Study:

  • To review the effects of various cancer chemotherapeutic agents in rodents across multiple cognitive domains.
  • To analyze the consistency and nuances of chemotherapy's impact on learning and memory in animal models.

Main Methods:

  • Review of rodent studies examining chemotherapy effects on sensory processing, learning, memory, and electrophysiology.
  • Analysis of dose- and time-dependency of chemotherapy-induced cognitive changes.

Main Results:

  • Observed inconsistencies in chemotherapy's effects across different cognitive models initially.
  • Emerging literature suggests subtle, dose- and time-dependent changes in sensory processing, acquisition, consolidation, and retrieval.

Conclusions:

  • Animal models are becoming more predictive for assessing chemotherapy-induced cognitive impairments.
  • Further research on combination therapies and repeated regimens will refine predictive models.
  • The ultimate goal is to inform clinical treatment choices and develop therapies to reduce cognitive side effects.