An efficient synthesis of hydantoins via sustainable integration of coupled domino processes
Meng Gao1, Yan Yang, Yan-Dong Wu
1Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Hubei, Wuhan 430079, PR China.
Abstract:
A highly efficient synthesis of hydantoins has been developed from simple and commercially available 1,3-dicarbonyl compounds, ureas, and methyl ketones or terminal aryl alkenes. This protocol involves a sustainable integration of two coupled domino processes: iodine-promoted synthesis of unsymmetrical 1,4-enediones (domino I) and the sequential transformation into hydantoins (domino II).
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