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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.

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Dupilumab therapy in atopic dermatitis when cutaneous lymphoma is suspected: Consensus recommendations from the EORTC Cutaneous Lymphoma Tumour Group.

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Related Experiment Video

Updated: Jun 9, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

[Cutaneous lymphomas].

Karin Schad1, Katrin Baumann Conzett, Antonio Cozzio

  • 1Dermatologische Klinik, UniversitätsSpital Zürich, Gloriastrasse, Zürich.

Therapeutische Umschau. Revue Therapeutique
|September 1, 2010
PubMed
Summary
This summary is machine-generated.

Cutaneous lymphomas are rare T- and B-cell cancers affecting the skin. Early stages are treated with skin-directed therapies, while advanced stages require systemic approaches and clinical study enrollment.

More Related Videos

Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors
08:39

Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors

Published on: January 7, 2019

Related Experiment Videos

Last Updated: Jun 9, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors
08:39

Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors

Published on: January 7, 2019

Area of Science:

  • Hematology
  • Dermatology
  • Oncology

Context:

  • Cutaneous lymphomas are rare extranodal Non-Hodgkin lymphomas primarily affecting the skin.
  • The skin is the second most common extranodal site for lymphoma after the GI tract.
  • The WHO/EORTC classification provides a standardized nomenclature for primary cutaneous lymphomas.

Purpose:

  • To review the classification, diagnosis, and treatment of cutaneous lymphomas.
  • To emphasize the importance of distinguishing primary from secondary cutaneous lymphomas.
  • To guide treatment strategies based on disease stage.

Summary:

  • Cutaneous lymphomas are heterogeneous lymphoproliferative disorders with low incidence.
  • The WHO/EORTC classification aids in diagnosis and clinical studies.
  • Treatment varies from skin-directed therapies for early stages to systemic approaches for advanced disease.
  • Distinguishing primary from secondary lymphomas prevents overtreatment of benign conditions.

Impact:

  • The WHO/EORTC classification facilitates international clinical research.
  • Accurate diagnosis and staging are crucial for appropriate treatment selection.
  • Enrollment in clinical studies is recommended for advanced-stage cutaneous lymphoma due to poor prognosis and lack of survival-improving therapies.