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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Updated: Jun 9, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
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Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

Sinonasal mucosal melanomas.

B Liétin1, A Montalban, C Louvrier

  • 1Service d'ORL et de chirurgie de la face et du cou, université d'Auvergne, CHU, BP 69, 58, rue Montalembert, 63003 Clermont-Ferrand cedex 01, France.

European Annals of Otorhinolaryngology, Head and Neck Diseases
|September 9, 2010
PubMed
Summary
This summary is machine-generated.

Sinonasal mucosal melanomas are aggressive, rare cancers. Early-stage tumors (T1) confined to the nasal fossae show a better prognosis, highlighting the importance of early detection for sinonasal melanoma patients.

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Area of Science:

  • Oncology
  • Head and Neck Surgery
  • Pathology

Background:

  • Sinonasal mucosal melanomas are rare, aggressive malignancies, comprising about 1% of all melanomas.
  • These tumors exhibit high recurrence rates (37-54%) and low 5-year survival (20-46%), with frequent metastases.

Purpose of the Study:

  • To analyze a series of sinonasal mucosal melanoma cases.
  • To identify prognostic factors influencing disease outcomes in these rare tumors.

Main Methods:

  • Retrospective analysis of ten sinonasal mucosal melanoma cases over ten years.
  • Inclusion of clinical, radiological, and anatomopathological data, alongside disease progression characteristics.
  • Comparison of findings with existing literature.

Main Results:

  • A 5-year overall survival rate of 40% was observed.
  • Seven patients experienced local recurrences, with three developing associated metastases.
  • Tumors classified as T1 and limited to the nasal fossae demonstrated a better prognosis.

Conclusions:

  • Sinonasal mucosal melanomas are rare with a high mortality rate.
  • Effective treatment necessitates extensive surgical intervention combined with external radiotherapy.