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Updated: Jun 9, 2026

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
Published on: July 8, 2025
Catatonia associated with initiating paliperidone treatment
Nathanael J McKeown1, James H Bryan, B Zane Horowitz
1Oregon Health & Science University, Department of Emergency Medicine, Oregon Poison Control Center, Portland VA.
Abstract:
We present a case of catatonia, which occurred shortly after starting a new antipsychotic, paliperidone, an active metabolite of risperidone. Catatonia may be caused by a variety of conditions, including metabolic, neurologic, psychiatric and toxic processes. Interestingly, risperidone, which has been thought to cause several cases of catatonia, has also been recommended as a potential treatment. We discuss potential mechanisms for causes of drug-induced catatonia as well as potential treatment options.
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