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Updated: Jun 9, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 14, 2010

[Kaposi's sarcoma interpreted as haematoma].

Jesper R Balle¹, Thomas Hasselager

¹Øre-, Naese- og Halskirurgisk Afdeling, Hillerød Hospital, 3400 Hillerød, Denmark. jesperballe@dadlnet.dk

Ugeskrift for Laeger

|September 10, 2010

Summary

Kaposi's sarcoma, a skin cancer common in HIV-positive individuals, rarely affects those with normal immune function. This case highlights its occurrence in an HIV-negative patient with a history of basal cell carcinoma.

Area of Science:

Oncology
Dermatology
Virology

Background:

Kaposi's sarcoma (KS) is a multifocal, angioproliferative neoplasm.
KS is strongly associated with human herpesvirus 8 (HHV-8) infection.
KS is a common malignancy in individuals with acquired immunodeficiency syndrome (AIDS).

Observation:

This report details a rare case of Kaposi's sarcoma affecting the face and scalp.
The patient was a human immunodeficiency virus (HIV)-negative male.
The patient had a history of basal cell carcinoma on his face.

Findings:

The occurrence of Kaposi's sarcoma in an HIV-negative, non-immune compromised individual is uncommon.
This presentation underscores that KS can arise in the absence of significant immunosuppression.

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The patient's prior history of basal cell carcinoma may be relevant to the development of KS.

Implications:

This case expands the clinical spectrum of Kaposi's sarcoma presentation.
It suggests a need for vigilance in diagnosing KS even in HIV-negative patients, particularly those with other risk factors.
Further research may elucidate alternative pathways for KS development beyond profound immunosuppression.