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Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
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Left ventricular noncompaction and myocardial fibrosis: a case report
Jagadeesh K Kalavakunta1, Hemasri Tokala, Aparna Gosavi
1Department of Internal Medicine: Division of Cardiology, Michigan State University/Kalamazoo Center for Medical Studies/Borgess Medical Center, Kalamazoo, MI, USA. vishalgupta@borgess.com.
International Archives of Medicine
|September 17, 2010
Summary
Left ventricular noncompaction (LVNC) is a rare genetic cardiomyopathy. Early diagnosis and intervention are crucial for managing this condition and reducing associated risks.
Area of Science:
- Cardiology
- Genetics
- Pathology
Background:
- Left ventricular noncompaction (LVNC) is a rare congenital abnormality.
- It is classified as a genetic cardiomyopathy, stemming from disrupted endomyocardial development.
- The mechanisms behind left ventricular dysfunction in LVNC, often appearing after age 40, remain poorly understood.
Purpose of the Study:
- To present a case of LVNC in an adult patient.
- To highlight the diagnostic features and management of LVNC.
- To emphasize the importance of physician awareness regarding LVNC.
Main Methods:
- A case report of a 60-year-old woman with shortness of breath.
- Diagnostic procedures included echocardiography, cardiac catheterization, and endomyocardial biopsy.
- Histological examination revealed endomyocardial fibrosis.
Main Results:
- Echocardiography showed noncompacted endocardium, indicative of LVNC.
- Cardiac catheterization and viral studies were normal.
- Histology confirmed endomyocardial fibrosis without disarray.
Conclusions:
- LVNC requires increased physician awareness due to high misdiagnosis rates and complications.
- Prompt diagnosis and intervention can significantly reduce morbidity and mortality.
- Family screening is recommended for individuals diagnosed with LVNC.
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