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Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Mapping brain anatomical connectivity using white matter tractography.

Mariana Lazar¹

¹Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY 10016, USA. mariana.lazar@nyumc.org

NMR in Biomedicine

|October 2, 2010

Summary

This summary is machine-generated.

White matter tractography reconstructs brain connectivity noninvasively using diffusion MRI. This technique maps neural pathways, aiding in understanding brain function and disorders.

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DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

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Published on: August 26, 2014

Area of Science:

Neuroscience
Medical Imaging
Computational Biology

Background:

Neural integration relies on white matter pathways connecting brain centers.
White matter tractography is the sole noninvasive in vivo method for reconstructing human brain anatomical connectivity.
This technique estimates pathway trajectories from diffusion MRI-derived nerve bundle orientations.

Purpose of the Study:

To review techniques for estimating fiber directions from diffusion measurements.
To describe white matter tractography methods and limitations.
To discuss applications in characterizing white matter connections and mapping functional brain systems.

Main Methods:

Diffusion MRI measurements to obtain local nerve bundle orientations.
Algorithms for estimating fiber directions from diffusion data.
Tractography methods to reconstruct white matter pathways.

Main Results:

Detailed review of fiber orientation estimation techniques.
Description of white matter tractography methodologies.
Discussion of current limitations such as image noise and partial voluming.

Conclusions:

White matter tractography is crucial for topographical characterization and segmentation of white matter pathways.
The technique has significant potential for mapping functional brain systems and their interrelations.
Applications extend to studying brain disorders, including tumor localization and identifying impaired connectivity in neurological diseases.