Initial study on facilitating wound healing after tooth extraction by using microbial fiber membrane-flagyl.

Area of Science:

• Biomaterials Science
• Oral Surgery
• Regenerative Medicine

Background:

• Tooth extraction is a common dental procedure.
• Post-extraction complications, such as delayed healing and inflammation, can occur.
• Novel biomaterials are needed to improve hemostasis and wound healing after extraction.

Purpose of the Study:

• To evaluate the efficacy of microbial fiber membrane-Flagyl (MF-FLA) in promoting hemostasis and wound healing.
• To assess the anti-inflammatory properties of MF-FLA following tooth extraction.
• To compare MF-FLA with traditional gauze for post-extraction socket management.

Main Methods:

• Histologic examination of mandibular samples in a rabbit model over 12 weeks.
• Clinical evaluation of 80 human patients undergoing bilateral tooth extraction.
• Comparison of MF-FLA treatment versus conventional gauze in human subjects.
• Assessment of wound depth and radiographic analysis at multiple time points.

Main Results:

• Histology showed MF-FLA promoted fibroblast and osteoblast growth and inhibited inflammatory cells in animal models.
• Clinical trials demonstrated superior hemostatic ability of MF-FLA compared to gauze.
• Significantly reduced wound depth (1.26 mm vs. 3.08 mm) observed in the MF-FLA group after 4 weeks (P < .01).
• Radiographic evidence indicated faster and more complete wound healing with MF-FLA.

Conclusions:

• MF-FLA effectively promotes early wound healing after tooth extraction.
• The material's biocompatibility, isolation, and anti-inflammatory properties support blood clot formation.
• MF-FLA reduces the incidence of post-extraction complications, offering a promising therapeutic option.