Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Generalist large language models complement tailor-made predictors for tumor genomics interpretation.

bioRxiv : the preprint server for biology·2026
Same author

Anti-Atherogenic Actions of Pomegranate Polyphenol Punicalagin and Its Metabolites: In Vitro Effects on Vascular Cells and In Vivo Atheroprotection by Urolithin A via Anti-Inflammatory and Plaque-Stabilising Mechanisms.

Antioxidants (Basel, Switzerland)·2026
Same author

Orthrus: toward evolutionary and functional RNA foundation models.

Nature methods·2026
Same author

The impact of the Lab4 probiotic on neurodegenerative processes in a murine Alzheimer's disease model.

Frontiers in neuroscience·2026
Same author

Resveratrol Mediates Anti-Atherogenic Actions In Vitro and in LDL Receptor-Deficient Mice Fed a High-Fat Diet via Antioxidant, Anti-Inflammatory and Plaque-Stabilising Activities.

Antioxidants (Basel, Switzerland)·2026
Same author

Inferring cancer type-specific patterns of metastatic spread using Metient.

Nature methods·2025
Same journal

Correction to 'New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress'.

Nucleic acids research·2026
Same journal

VeloRM: disentangling pre- and post-splicing RNA modification dynamics at single-cell resolution.

Nucleic acids research·2026
Same journal

Accessibility of telomeric overhangs to stabilizing small-molecule ligands.

Nucleic acids research·2026
Same journal

Multivalent interactions mediate SNAIL transcription factor stimulation of the nucleosome deacetylase activity of the CoREST complex.

Nucleic acids research·2026
Same journal

Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions and transcription start sites.

Nucleic acids research·2026
Same journal

Correction to 'The Gene Ontology knowledgebase in 2026'.

Nucleic acids research·2026
See all related articles

Related Experiment Video

Updated: Jun 7, 2026

An Optimized Quantitative Pull-Down Analysis of RNA-Binding Proteins Using Short Biotinylated RNA
07:55

An Optimized Quantitative Pull-Down Analysis of RNA-Binding Proteins Using Short Biotinylated RNA

Published on: February 17, 2023

RBPDB: a database of RNA-binding specificities.

Kate B Cook1, Hilal Kazan, Khalid Zuberi

  • 1Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada.

Nucleic Acids Research
|November 2, 2010
PubMed
Summary
This summary is machine-generated.

The RNA-Binding Protein DataBase (RBPDB) compiles experimental RNA-binding site data for 272 RNA-binding proteins (RBPs) across four species. This resource aids researchers in understanding RBP interactions and functions.

More Related Videos

A Rapid High-throughput Method for Mapping Ribonucleoproteins (RNPs) on Human pre-mRNA
13:00

A Rapid High-throughput Method for Mapping Ribonucleoproteins (RNPs) on Human pre-mRNA

Published on: December 2, 2009

Novel RNA-Binding Proteins Isolation by the RaPID Methodology
11:19

Novel RNA-Binding Proteins Isolation by the RaPID Methodology

Published on: September 30, 2016

Related Experiment Videos

Last Updated: Jun 7, 2026

An Optimized Quantitative Pull-Down Analysis of RNA-Binding Proteins Using Short Biotinylated RNA
07:55

An Optimized Quantitative Pull-Down Analysis of RNA-Binding Proteins Using Short Biotinylated RNA

Published on: February 17, 2023

A Rapid High-throughput Method for Mapping Ribonucleoproteins (RNPs) on Human pre-mRNA
13:00

A Rapid High-throughput Method for Mapping Ribonucleoproteins (RNPs) on Human pre-mRNA

Published on: December 2, 2009

Novel RNA-Binding Proteins Isolation by the RaPID Methodology
11:19

Novel RNA-Binding Proteins Isolation by the RaPID Methodology

Published on: September 30, 2016

Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Genomics

Background:

  • RNA-binding proteins (RBPs) play crucial roles in gene regulation.
  • Experimental data on RBP binding sites is scattered across scientific literature.
  • A centralized, curated database is needed to facilitate RBP research.

Purpose of the Study:

  • To create a comprehensive database of experimentally determined RNA-binding sites.
  • To curate and organize binding data for RBPs in metazoan species.
  • To provide a user-friendly interface for accessing and analyzing RBP binding information.

Main Methods:

  • Manual curation of experimental binding data from primary literature.
  • Literature searches for RBPs with known RNA-binding domains in human, mouse, fly, and worm.
  • Inclusion of both in vitro and in vivo binding observations.

Main Results:

  • The RNA-Binding Protein DataBase (RBPDB) contains data for 272 RBPs.
  • Includes 71 RBPs with position weight matrix motifs.
  • Features 36 sets of in vivo-bound transcript sequences from immunoprecipitation experiments.

Conclusions:

  • RBPDB provides a valuable, freely accessible resource for RBP research.
  • The database facilitates browsing, searching, and data export.
  • Enables sequence scanning for RBP-binding sites, aiding functional studies.