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Updated: Jun 7, 2026

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
Published on: March 31, 2021
[Dental caries in an ecological perspective]
Svante Twetman1, Kim Ekstrand, Vibeke Qvist
1Københavns Universitet, Det Sundhedsvidenskabelige Fakultet, Odontologisk Institut, Afdeling for Cariologi og Endodonti, København N, Denmark. stwe@sund.ku.dk
Abstract:
Dental caries affects the majority of the Danish population. Its aetiology is multi-factorial, but a pH-induced change in the homeostasis of the oral biofilm leading to overgrowth of acid-tolerating bacteria is a key event. A non-invasive concept for prevention and management is emerging based on the common risk factor approach. There is strong evidence that tooth brushing twice a day with fluoridated toothpaste is the most cost-effective way to prevent and control caries development. Physicians need to consider that a number of drugs may affect the saliva flow rate, which increases the caries risk.
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