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Updated: Jun 6, 2026

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Published on: October 3, 2018
Oxygen catalyzed mobilization of iron from ferritin by iron(III) chelate ligands
Fadi Bou-Abdallah1, Justin McNally, Xing Xin Liu
1State University of New York at Potsdam, Department of Chemistry, Potsdam, New York, USA. bouabdf@potsdam.edu
Abstract:
Tridentate chelate ligands of 2,6-bis[hydroxy(methyl)amino]-1,3,5-triazine family rapidly release iron from human recombinant ferritin in the presence of oxygen. The reaction is inhibited by superoxide dismutase, catalase, mannitol and urea. Suggested reaction mechanism involves reduction of the ferritin iron core by superoxide anion, diffusion of iron(II) cations outside the ferritin shell, and regeneration of superoxide anions through oxidation of iron(II) chelate complexes with molecular oxygen.
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