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Related Concept Videos

Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Birth Control Methods01:22

Birth Control Methods

Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although vasectomy...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
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Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
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Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
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Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...

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Updated: Jun 6, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Oral contraceptive use and bone.

Shuying Wei1, Tania Winzenberg, Laura L Laslett

  • 1Menzies Research Institute, University of Tasmania, Private bag 23, Hobart, Tasmania 7000, Australia. Shuying.Wei@utas.edu.au

Current Osteoporosis Reports
|November 25, 2010
PubMed
Summary
This summary is machine-generated.

Oral contraceptive (OC) use in women has mixed effects on bone mass, with some evidence suggesting no harm or even benefits. Further research is needed on optimal OC dosage and timing for adolescents.

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Osteoclast Derivation from Mouse Bone Marrow
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Osteoclast Derivation from Mouse Bone Marrow

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Last Updated: Jun 6, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Osteoclast Derivation from Mouse Bone Marrow
06:17

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

Area of Science:

  • Endocrinology
  • Bone Biology
  • Reproductive Health

Background:

  • Sex hormones are crucial for maintaining bone homeostasis.
  • The impact of oral contraceptives (OCs) on bone mass in women is debated.
  • Existing research presents conflicting findings regarding OC use and bone health.

Purpose of the Study:

  • To critically review scientific literature on the association between oral contraceptive use and bone mass.
  • To analyze studies published between January 2009 and August 2010.
  • To identify gaps in knowledge and recommend future research directions.

Main Methods:

  • Systematic review of published studies.
  • Focus on research concerning oral contraceptive use and bone mass in adolescents and young adults.
  • Analysis of studies examining effects on bone mass and bone turnover markers.

Main Results:

  • Studies predominantly focused on adolescents and young adults, yielding mixed results on bone mass.
  • Limited evidence suggests OCs may have no adverse effect or a beneficial impact on bone mass, with exceptions for early post-menarche initiation.
  • A consistent negative effect of OCs was observed on bone turnover markers.

Conclusions:

  • The relationship between oral contraceptive use and bone mass remains controversial.
  • Conflicting results exist regarding ultra-low-dose OCs (20 μg ethinyl estradiol) in adolescents and young adults.
  • High-quality prospective studies, including randomized trials, are necessary to determine optimal OC dosage and initiation timing for adolescent contraception.