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1Abteilung Endokrinologie/Diabetologie, Departement Medizin, Luzerner Kantonsspital, Luzern. christoph.henzen@ksl.ch
Therapeutische Umschau. Revue Therapeutique
|November 26, 2010
Summary
Acromegaly, a rare endocrine disorder, causes growth hormone excess leading to serious health issues. Early diagnosis and treatment, including surgery and medication, are crucial to manage symptoms and reduce mortality risks.
Area of Science:
- Endocrinology
- Rare Diseases
- Oncology
Background:
- Acromegaly is a rare endocrine disorder characterized by insidious onset and delayed diagnosis.
- It results from excessive growth hormone (GH) production, often due to pituitary tumors.
Observation:
- Key clinical signs include acral enlargement, prognathism, hyperhidrosis, and skin thickening.
- Cardiorespiratory comorbidities significantly increase mortality threefold compared to the general population.
Findings:
- Diagnosis is confirmed by elevated insulin-like growth factor 1 (IGF-1) and human growth hormone (hGH) levels post-glucose load.
- Pituitary macroadenoma is identified via MRI in over 90% of cases; ectopic sources are rare.
Implications:
- Treatment aims to halt GH overproduction and prevent complications.
- Therapeutic options include transsphenoidal surgery, pharmacotherapy (somatostatin analogs, pegvisomant, dopamine agonists), and radiosurgery.
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