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Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Drug Delivery: Overview01:16

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
Drug Distribution: Tissue Binding01:21

Drug Distribution: Tissue Binding

Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
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Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization
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Published on: September 2, 2022

Affinity-based drug delivery.

Nick X Wang1, Horst A von Recum

  • 1Department of Biomedical Engineering, Case Western Reserve University, 220 Wickenden Building, 10900 Euclid Ave, Cleveland, OH 44106, USA.

Macromolecular Bioscience
|November 26, 2010
PubMed
Summary
This summary is machine-generated.

Affinity-based drug delivery systems use specific interactions to control drug loading and release. This review covers molecular imprinting, growth factor, and cyclodextrin systems, exploring their current state and future potential.

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Affinity-based drug delivery systems leverage specific molecular interactions between drugs and delivery vehicles.
  • These interactions enable precise control over drug loading efficiency and release kinetics.
  • This approach offers a significant advancement over traditional drug delivery methods.

Purpose of the Study:

  • To provide a comprehensive overview of affinity-based drug delivery systems.
  • To detail the synthesis, therapeutic factor types, and loading/release mechanisms.
  • To examine current research, breakthroughs, challenges, and future directions.

Main Methods:

  • Review of scientific literature on affinity-based drug delivery.
  • Categorization of systems into molecular imprinting, growth-factor delivery, and cyclodextrin-based delivery.
  • Analysis of synthesis strategies, loading capacities, and release profiles.

Main Results:

  • Detailed discussion of three main types of affinity-based drug delivery systems.
  • Identification of key advancements in controlling drug loading and release.
  • Highlighting of challenges in system stability, scalability, and in vivo performance.

Conclusions:

  • Affinity-based drug delivery systems represent a promising frontier in targeted and controlled therapeutics.
  • Further research is needed to overcome current limitations and translate these systems into clinical applications.
  • The potential impact spans various therapeutic areas, offering enhanced efficacy and reduced side effects.