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Updated: Jun 6, 2026

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy
Published on: July 12, 2021
Afebrile pediatric seizures
Ghazala Q Sharieff1, Phyllis L Hendry
1Department of Emergency Medicine, Palomar-Pomerado Health System/California Emergency Physicians, 3020 Children's Way, San Diego, CA 92011, USA.
Insights
Most children with afebrile seizures can be treated as outpatients. Laboratory tests and neuroimaging are typically unnecessary unless specific clinical factors are present, simplifying pediatric seizure management.
Area of Science:
- Pediatric Neurology
- Clinical Management of Seizures
Background:
- Afebrile seizures are common in children.
- Current management guidelines for afebrile seizures require clear definition.
Purpose of the Study:
- To define the optimal outpatient management strategy for children experiencing an afebrile seizure.
- To identify specific indications for laboratory studies and neuroimaging in pediatric afebrile seizures.
Main Methods:
- Review of clinical presentation and management of children with afebrile seizures.
- Analysis of factors influencing the need for laboratory investigations and neuroimaging.
Main Results:
- Well-appearing children with afebrile seizures can be managed outpatient with EEG and PCP follow-up.
- Laboratory studies are indicated for infants <6 months, prolonged seizures, altered consciousness, metabolic disorders, or dehydration.
- Emergent neuroimaging is not recommended for first unprovoked afebrile seizures but considered for predisposing conditions or focal seizures in children <3 years.
Conclusions:
- Outpatient management is appropriate for most children with afebrile seizures.
- Selective use of laboratory studies and neuroimaging based on clinical criteria can optimize care and resource utilization.
Abstract:
Most well-appearing children who have had an afebrile seizure can be managed as outpatients with instructions for an outpatient electroencephalogram and primary care physician follow-up. Laboratory studies are needed only in children younger than 6 months, in patients with prolonged seizures or altered level of consciousness, or in those with history of a metabolic disorder or dehydration. Emergent neuroimaging is not recommended in children with a first unprovoked afebrile seizure, although studies should be considered in children with a predisposing condition or focal seizures if younger than 3 years.
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