Non-invasive analysis of turbid samples using deep Raman spectroscopy

Area of Science:

• Optics and Photonics
• Analytical Chemistry
• Biomedical Spectroscopy

Background:

• Conventional Raman spectroscopy is limited in analyzing diffusely scattering samples at depth.
• Recent technological advancements have overcome these limitations.
• Spatially offset Raman spectroscopy (SORS) and transmission Raman spectroscopy (TRS) are key innovations.

Purpose of the Study:

• To review recent developments in deep non-invasive characterization of diffusely scattering samples using Raman spectroscopy.
• To highlight the societal relevance of these emerging research activities.
• To focus on advancements in SORS and TRS.

Main Methods:

• Utilizes spatially offset Raman spectroscopy (SORS).
• Employs transmission Raman spectroscopy (TRS).
• Focuses on non-invasive characterization of diffusely scattering materials.

Main Results:

• Demonstrates deep penetration for sample analysis.
• Enables characterization of samples not accessible by conventional Raman.
• Highlights successful applications in diverse fields.

Conclusions:

• Advanced Raman techniques like SORS and TRS are revolutionizing non-invasive analysis.
• These methods have high societal impact in healthcare, pharmaceuticals, and security.
• The field is rapidly evolving with significant future potential.