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A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage
Published on: July 28, 2018
Vasospasm after subarachnoid hemorrhage: a 3D rotational angiography study
Guo-En Yao1, Qi Li, Xiao-Jiang Jiang
1Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Acta Neurochirurgica. Supplement
|December 3, 2010
Summary
3D rotational angiography (3DRA) showed high sensitivity for detecting cerebral vasospasm after subarachnoid hemorrhage (SAH). However, 2D digital subtraction angiography (DSA) remains more useful due to frequent pseudo-spasm on 3DRA.
Area of Science:
- Neuroimaging
- Vascular Neurology
- Radiology
Background:
- Cerebral vasospasm is a serious complication of aneurysmal subarachnoid hemorrhage (SAH).
- Accurate detection and characterization of vasospasm are crucial for timely treatment.
- 3D rotational angiography (3DRA) offers advanced visualization compared to conventional 2D digital subtraction angiography (DSA).
Purpose of the Study:
- To evaluate the clinical utility of 3D rotational angiography (3DRA) for assessing cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage (SAH).
- To compare the diagnostic performance of 3DRA with the established standard, 2D digital subtraction angiography (DSA).
Main Methods:
- Retrospective analysis of 46 patients with aneurysmal SAH who underwent both 2D DSA and 3DRA.
- 3DRA was performed following standard 2D DSA.
- 3D volume rendering images from 3DRA were compared with 2D DSA for vasospasm detection and characterization.
Main Results:
- 25 out of 46 patients showed vasospasm on 2D DSA.
- 3DRA detected 51 spastic segments compared to 46 on DSA.
- 3DRA demonstrated 100% sensitivity, 76% specificity, 90% positive predictive value, and 100% negative predictive value for vasospasm detection.
Conclusions:
- 3D rotational angiography (3DRA) is highly sensitive but frequently shows pseudo-spasm.
- The occurrence of pseudo-spasm on 3DRA volume rendering images limits its utility.
- 2D digital subtraction angiography (DSA) remains a more reliable method for evaluating cerebral vasospasm post-SAH.
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