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[Children prefer bottled amoxicillin]

Anton Pottegård1, Jesper Hallas

  • 1Afdeling for Klinisk Farmakologi, Syddansk Universitet, 5000 Odense C, Denmark.

Ugeskrift for Laeger
|December 16, 2010
PubMed

Insights

Children prefer bottled amoxicillin over phenoxymethylpenicillin, as indicated by prescription data. Early prescription switches suggest lower acceptance of phenoxymethylpenicillin in pediatric patients.

Area of Science:

  • Pharmacology
  • Pediatric Medicine
  • Pharmacoepidemiology

Background:

  • Assessing penicillin acceptance in children is crucial for effective treatment.
  • Large-scale prescription data can provide insights into treatment adherence and preferences.

Purpose of the Study:

  • To determine which penicillin formulation is most widely accepted by children.
  • To identify potential taste-related therapeutic failures based on prescription patterns.

Main Methods:

  • Utilized the Odense PharmacoEpidemiological Database (OPED) for prescription data from 2009.
  • Analyzed penicillin prescriptions issued to children in the Region of Southern Denmark.
  • Calculated the rate of early switch (within three days) as a proxy for acceptance.

Main Results:

  • Examined 253,018 penicillin prescriptions for 90,054 children.
  • Identified 2,599 early switches among Primcillin, Imacillin, and Flemoxin.
  • Phenoxymethylpenicillin (Primcillin) showed a 14.7 times higher risk of switch compared to amoxicillin (Imacillin).

Conclusions:

  • Phenoxymethylpenicillin demonstrates significantly lower acceptance among children.
  • Children exhibit a preference for bottled amoxicillin formulations over phenoxymethylpenicillin.
Abstract

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