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Updated: Jun 5, 2026

A Modified Simple Method for Induction of Myocardial Infarction in Mice
Published on: December 3, 2021
Pharmacological correction of testosterone deficiency during experimental myocardial ischemia
L K Khnychenko1, I V Okunevich, Yu O Fedotova
1Department of Neuropharmacology, Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia. sns@iem.spb.ru
Abstract:
Experiments on rats with myocardial ischemia modeled by occlusion of the left coronary artery aggravated by alimentary dislipoproteinemia showed that therapy with taurepar (50 mg/kg), a taurine derivative, decreased blood corticosterone concentration and increased the level of endogenous testosterone, which attests to normalization of the compensatory-adaptive and gonadotropic functions of the organism.

