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Updated: Jun 5, 2026

Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis
Published on: December 8, 2011
Efficiency of lyticase (bacterial enzyme) in experimental candidal vaginitis in mice
N P Sachivkina1, E G Kravtsov, E A Wasileva
1Department of Microbiology, Russian University of Peoples' Friendship, Moscow, Russia.
Abstract:
Lyticase (a bacterial enzyme) was tested as a new antimycotic drug. Of all objects studied, Cellulomonas cellulans AC-870 strain proved to be most productive for this enzyme. A technology for lyticase isolation and purification was proposed. An experimental model of recurrent vaginal candidiasis was created. The model includes combined antibiotic and estradiol therapy. Antimycotic effect of lyticase on the model of recurrent vaginal candidiasis in mice was demonstrated.

