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Published on: October 13, 2018
Genetic variability of spermatozoon production and morphology in laboratory mice
1Laboratory of Endocrinological Genetics, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. losadch@bionet.nsc.ru
Abstract:
Strain-specific differences in the production of spermatozoa and incidence of atypical spermatogenesis were studied in males of 7 inbred strains: BALB/cLac, PT, CBA/Lac, DD, A/He, C57Bl/6J, and YT. The results attest to significant genetic variability of the counts of epididymal spermatozoa (differing by more than 1.5-2 times) and incidence of abnormal spermatozoon heads (differing by more than 4 times). However, the strain-specific variability of both signs was not coordinated. The selected set of inbred mouse strains can become a prospective genetic model for studies of physiological and hereditary nature of spermatogenesis variability.
