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Steroid Hormones in Seminal Plasma: the Relationship with Sperm Quality
L V Osadchuk1, M A Kleshchev2, A V Osadchuk2
1Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. losadch@bionet.nsc.ru.
Bulletin of Experimental Biology and Medicine
|February 1, 2023
Summary
Seminal estradiol levels may predict sperm quality and aid in diagnosing impaired spermatogenesis. Higher seminal estradiol in men with poor sperm parameters suggests its role as a biological indicator.
Area of Science:
- Reproductive Endocrinology
- Andrology
- Sperm Biology
Background:
- Hormonal imbalances can impact male fertility.
- Understanding the role of seminal hormones in spermatogenesis is crucial for diagnosing infertility.
Purpose of the Study:
- To investigate seminal testosterone and estradiol as prognostic markers for normal spermatogenesis.
- To determine if these hormones can characterize sperm pathology.
Main Methods:
- Analysis of serum and seminal steroid hormones in 269 healthy young males.
- Evaluation of sperm concentration, motility, and morphology.
Main Results:
- Seminal testosterone was lower and seminal estradiol was higher than serum levels.
- Both seminal testosterone and estradiol negatively correlated with sperm concentration.
- Elevated seminal estradiol was observed in men with pathozoospermia.
Conclusions:
- Seminal estradiol may serve as a biological predictor of normal spermatogenesis and sperm quality.
- Seminal estradiol can be a valuable diagnostic tool for impaired spermatogenesis, particularly when related to estrogen excess.
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