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Updated: Jun 5, 2026
09:56
A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
Published on: February 21, 2025
[Research progress on second-hit in malignant lymphomagenesis-- review]
1Department of Hematology, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi
|December 24, 2010
Summary
Mutated stem/progenitor cells can cause cancer. This review explores the
Area of Science:
- Oncology and Stem Cell Biology
- Molecular Biology and Genetics
Context:
- Stem/progenitor cells are crucial for organ development but their mutations can lead to diseases, including cancer.
- Cancer stem/progenitor cells share self-renewal and differentiation abilities with normal stem/progenitor cells, suggesting a common origin.
- Recent research indicates that non-Hodgkin's lymphomas originate from mutated lymphocytic progenitor cells, with a 'second-hit' exacerbating mutations.
Purpose:
- To review current advancements in understanding the role of the 'second-hit' in stem/progenitor cells during oncogenesis.
- To explore the contribution of stem/progenitor cell mutations to the development of B-cell non-Hodgkin's lymphoma.
Summary:
- Mutations in stem/progenitor cells are implicated in various human diseases, notably cancer.
- The concept of cancer stem/progenitor cells highlights shared characteristics with normal stem/progenitor cells.
- The 'second-hit' mechanism in lymphocytic progenitor cells is identified as a key factor in B-cell non-Hodgkin's lymphoma initiation.
Impact:
- Provides insights into the oncogenic mechanisms of B-cell non-Hodgkin's lymphoma.
- Highlights the critical role of stem/progenitor cell mutations in cancer development.
- Informs potential therapeutic strategies targeting cancer stem/progenitor cells.
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