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Updated: Jun 5, 2026
Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
Published on: September 14, 2010
[Current alteration of K(V) channel in SLE patient's peripheral blood lymphocytes and it's significant]
Yan He1, Xiao-Xia Sun, Wen-Jie Zhang
1Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, Tianjin 300050, China.
Aim:
To observe the property alteration of K(v) channel in SLE patient's peripheral blood lymphocyte and its significant.
Methods:
The patch-clamp technique was used to record the current of K(V) channel in SLE patient's peripheral lymphocyte.
Results:
The current amplitude of K(V) channel in the SLE patient's lymphocytes decreased, it was (258.6 +/- 112.5) pA in healthy people, but in SLE patient it was (139.4 +/- 58.5) pA (P < 0.05). There was no other changes in the property of channel, include activation potential, inactivation property, channel closing kinetics and its pharmacological property.
Conclusion:
The decline of SLE patient's cell immunity may be related to the decrease of the amplitude of K(V) channel current.
