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Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
2,2-Dichloro-N-(phenyl-sulfon-yl)-acetamide
Acta Crystallographica. Section E, Structure Reports Online
|January 5, 2011
Summary
The molecular structure of C(8)H(7)Cl(2)NO(3)S reveals trans conformations for key bonds. Molecules self-assemble into linear chains through N-H⋯O hydrogen bonds, influencing crystal packing.
Area of Science:
- Crystallography
- Molecular Chemistry
- Supramolecular Chemistry
Background:
- Understanding molecular conformation is crucial for predicting chemical properties.
- Hydrogen bonding plays a vital role in the self-assembly of molecules.
Purpose of the Study:
- To determine the solid-state conformation of the title compound, C(8)H(7)Cl(2)NO(3)S.
- To investigate the intermolecular interactions and resulting supramolecular architecture.
Main Methods:
- Single-crystal X-ray diffraction was employed to analyze the molecular structure.
- Analysis of bond lengths, bond angles, and dihedral angles provided conformational details.
Main Results:
- The N-H and C=O bonds within the molecule adopt a trans conformation.
- A dihedral angle of 79.75° was observed between the benzene ring and the SO(2)-NH-CO-C group.
- Linear chains were formed through N-H⋯O hydrogen bonding.
Conclusions:
- The study elucidates the specific molecular geometry and conformational preferences of C(8)H(7)Cl(2)NO(3)S.
- The observed hydrogen bonding pattern dictates the formation of extended supramolecular structures in the solid state.
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