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Protein-ligand binding investigated by a single nanoparticle TERS approach

Stacey L Carrier1, Corey M Kownacki, Zachary D Schultz

  • 1University of Notre Dame, Department of Chemistry and Biochemistry, Notre Dame, IN, USA.

Chemical Communications (Cambridge, England)
|January 6, 2011
PubMed
Abstract

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Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...