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Updated: Jun 5, 2026

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Epigenetic memory meets G2/M: to remember or to forget?
Jafar Sharif1, Mitsuhiro Endoh, Haruhiko Koseki
1RIKEN Center for Allergy and Immunology, 1-7-22 Suehiro, Tsurumi-ku, Yokohama 230-0045, Japan.
Abstract:
The histone H3 lysine 27 (H3K27) methyltransferase EZH2 is essential for stem cell maintenance and proliferation. Recent insights suggest that the cyclin-dependent kinase CDK1 phosphorylates EZH2 at specific threonine residues by sensing developmental cues to mediate self-renewal or differentiation during G2/M phase.
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