Related Experiment Video

Updated: Jun 5, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

A biomimetic approach to the cylindrospermopsin alkaloids

Daniel M Evans1, Patrick J Murphy

  • 1School of Chemistry, Bangor University, Bangor, Gwynedd, UK LL33 0SE.

Chemical Communications (Cambridge, England)
|January 26, 2011
PubMed

Abstract:

The tethered Biginelli condensation between hemiaminal 21 and β-keto ester 22 is reported, leading to a model tricyclic core of the cylindrospermopsin alkaloids.

More Related Videos

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
07:11

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Published on: September 28, 2022

Biomimetic Replication of Root Surface Microstructure using Alteration of Soft Lithography
05:53

Biomimetic Replication of Root Surface Microstructure using Alteration of Soft Lithography

Published on: August 5, 2020

Related Experiment Videos

Last Updated: Jun 5, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
07:11

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Published on: September 28, 2022

Biomimetic Replication of Root Surface Microstructure using Alteration of Soft Lithography
05:53

Biomimetic Replication of Root Surface Microstructure using Alteration of Soft Lithography

Published on: August 5, 2020

Related Concept Videos

Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship01:22

Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship

Cholinergic agonists or cholinomimetics mimic the action of acetylcholine to stimulate the parasympathetic nervous system. They are categorized into direct-acting and indirect-acting agents. The direct-acting cholinergic drugs induce the parasympathetic response by directly binding to the muscarinic or nicotine receptors. In comparison, the indirect-acting cholinergic drugs prevent acetylcholine hydrolysis, indirectly contributing to the extended parasympathetic response.
The direct-acting...

Articles linked to this work by shared authors, journal, and citation graph.

A step-by-step guide for isolating soluble and insoluble chromatin followed by next-generation sequencing library preparation.

STAR protocols·2026

Proliferative Periostitis: Often Overlooked Onion-Skinning.

Head and neck pathology·2026

Protocol for mapping insertion sites of Tol2 transgenes in zebrafish using TransTag.

STAR protocols·2025

CUT&Tag overcomes biases of ChIP and establishes chromatin patterns for repetitive genomic loci.

iScience·2025

TransTag enables simple and efficient transgene mapping in zebrafish via tagmentation.

Cell reports methods·2025

Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis.

Nature aging·2025

A bifunctional supramolecular modulator regulating solvation and interfacial chemistry for stable lithium metal batteries.

Chemical communications (Cambridge, England)·2026

Decoding Pt-electrolyte-ionomer interactions during the oxygen reduction reaction via operando FTIR.

Chemical communications (Cambridge, England)·2026

Ag(I)-catalyzed stereoselective synthesis of β-haloenamines via unconventional solvent-sourced halogenation.

Chemical communications (Cambridge, England)·2026

Beyond phosphines: phosphine-free manganese catalysts for the green generation and shuttling of hydrogen for sustainable transformation.

Chemical communications (Cambridge, England)·2026

Thermally reversible Diels-Alder linkers enable reusable methacrylate supports for enzyme immobilisation.

Chemical communications (Cambridge, England)·2026

Unveiling the catalytic synthesis of macrolactams from nitro-alcohols: a single-catalyst two-step strategy integrating hydrogen auto-transfer and acceptorless dehydrogenation.

Chemical communications (Cambridge, England)·2026

Synthetic Anionophores Enhance the Activity of Anionic Drugs.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026

Programmed S → N Remote Cyano Migration: A Thiocyanate-Based Entry to Cyanamides and Selective Ferroptosis Inducers.

ACS central science·2026

Structure-activity relationship study on the antibacterial properties of B-ring brominated 1,3-dithiolium flavonoids.

RSC advances·2026

Controlling phosphorus(v)-stereogenicity via organocatalytic acylative desymmetrisation of bisphenols.

Chemical science·2026

Phytochemical Profiling and Antibacterial Activity of Moroccan Monofloral Honeys Against Multidrug-Resistant Uropathogens: In Vitro, ADMET, Molecular Docking, and Molecular Dynamics Approaches.

Food science & nutrition·2026

Modular and Stereoselective Synthesis of Cyclobutane β-Amino Alcohols.

Angewandte Chemie (International ed. in English)·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us