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Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
04:11

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Frequency of hepatitis D virus infection in hepatitis B surface antigen-positive liver diseases

Majid Ahmed Shaikh1, Wazir Muhammad Shaikh, Ghulam Akber Solangi

  • 1Medical Unit-V, Civil Hospital/Dow University of Health Sciences, Karachi. majidwazir@hotmail.com

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|February 1, 2011
PubMed

Insights

Hepatitis D Virus (HDV) infection is common in patients with Hepatitis B Virus (HBV)-positive liver disorders, particularly chronic cases. Awareness of this dual infection risk is crucial for healthcare providers.

Area of Science:

  • Hepatology
  • Virology
  • Infectious Diseases

Background:

  • Hepatitis B Virus (HBV) infection is a significant global health concern.
  • Hepatitis D Virus (HDV) is a unique RNA virus that requires HBV for replication, leading to HBV/HDV co-infection.
  • Understanding the prevalence of HDV in HBV-positive liver disorders is essential for effective management.

Purpose of the Study:

  • To determine the frequency of HDV in patients with HBsAg-positive liver disorders.
  • To analyze the prevalence of HDV based on gender and age groups.
  • To identify differences in HDV frequency between acute and chronic liver conditions.

Main Methods:

  • An observational, cross-sectional study was conducted.
  • Adult patients with HBsAg-positive liver disorders were enrolled.
  • Anti-HDV antibodies were detected using ELISA kits, with statistical analysis performed.

Main Results:

  • Out of 774 patients, 183 (23.6%) tested positive for anti-HDV.
  • HDV prevalence did not significantly differ between genders (p=0.718).
  • HDV infection was significantly more common in chronic liver disorders compared to acute ones.

Conclusions:

  • HBV/HDV co-infection is frequent in the studied population.
  • Healthcare practitioners and managers need to be aware of the high risk of dual HBV and HDV infection.
  • This highlights the importance of diagnostic testing for HDV in HBV-positive patients.
Abstract

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