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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.

Long-term Potentiation

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Related Experiment Video

Updated: Jun 4, 2026

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

TRPM1: new trends for an old TRP.

Elena Oancea¹, Nadine L Wicks

¹Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI, USA. Elena_Oancea@brown.edu

Advances in Experimental Medicine and Biology

|February 4, 2011

Summary

Transient Receptor Potential Melastatin 1 (TRPM1) channels are crucial for vision and skin pigmentation. Recent findings reveal novel splice variants and functions, including roles in retinal ON bipolar cells and melanocytes.

Area of Science:

Molecular Biology
Neuroscience
Dermatology

Background:

TRPM1 (Transient Receptor Potential Melastatin 1), the first identified TRPM channel, has long-eluded detailed characterization.
Recent advancements have shed light on its molecular properties and physiological roles.

Purpose of the Study:

To review the current understanding of TRPM1, covering its discovery, expression, regulation, and functions.
To discuss the significance of TRPM1 in skin and eye physiology.

Main Methods:

Literature review and synthesis of recent research findings.
Analysis of genetic and functional studies related to TRPM1.

Main Results:

Identification of novel TRPM1 splice variants.

More Related Videos

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

Related Experiment Videos

Last Updated: Jun 4, 2026

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

TRPM1 is essential for non-selective cation conductance in melanocytes and retinal bipolar cells.

TRPM1 mediates retinal ON bipolar cell transduction and influences melanocyte pigmentation.

Conclusions:

TRPM1 plays critical roles in both the visual system and skin.
TRPM1 mutations are linked to congenital stationary night blindness, highlighting its clinical relevance.