Related Experiment Video
Updated: Jun 4, 2026

Cell Type-specific Gene Expression Profiling in the Mouse Liver
Published on: September 17, 2019
Expression and function of TRP channels in liver cells
Grigori Y Rychkov1, Gregory J Barritt
1Department of Physiology, University of Adelaide, Adelaide, SA 5001, Australia. grigori.rychkov@adelaide.edu.au
Abstract:
The liver plays a central role in whole body homeostasis by mediating the metabolism of carbohydrates, fats, proteins, drugs and xenobiotic compounds, and bile acid and protein secretion. Hepatocytes together with endothelial cells, Kupffer cells, smooth muscle cells, stellate and oval cells comprise the functioning liver. Many members of the TRP family of proteins are expressed in hepatocytes. However, knowledge of their cellular functions is limited. There is some evidence which suggests the involvement of TRPC1 in volume control, TRPV1 and V4 in cell migration, TRPC6 and TRPM7 in cell proliferation, and TRPPM in lysosomal Ca(2+) release. Altered expression of some TRP proteins, including TRPC6, TRPM2 and TRPV1, in tumorigenic cell lines may play roles in the development and progression of hepatocellular carcinoma and metastatic liver cancers. It is likely that future experiments will define important roles for other TRP proteins in the cellular functions of hepatocytes and other cell types of which the liver is composed.
More Related Videos
12:09Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
Published on: December 31, 2013
08:27Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
Published on: January 7, 2019
Related Concept Videos
Cell Specific Gene Expression
Repressible Operon: trp Operon
Thermosensation
Enzyme-linked Receptors
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Liver Physiology
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can also...
Hepatic Drug Clearance: Role of Transporters