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Updated: Jun 4, 2026

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents
Published on: September 16, 2020
Oxygen therapy for diabetic macular ischemia: a pilot study.
Farideh Sharifipour1, Masoud Soheilian, Esmaeil Idani
1Department of Ophthalmology, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. fsharifipour@ajums.ac.ir
Systemic oxygen therapy reduced central macular thickness and improved retinal function in diabetic macular ischemia patients. This treatment shows promise for improving retinal structure and electrophysiology.
Area of Science:
- Ophthalmology
- Diabetic Retinopathy
- Macular Ischemia
Background:
- Diabetic macular ischemia is a significant complication of diabetes mellitus.
- Current treatments for diabetic macular ischemia have limitations.
Purpose of the Study:
- To investigate the effects of systemic oxygen therapy on diabetic macular ischemia.
- To evaluate changes in retinal structure and function following oxygen administration.
Main Methods:
- An interventional case series involving 20 eyes from 13 diabetic patients.
- Optical coherence tomography and electroretinography were performed before and after 1-hour oxygen therapy.
- Central macular thickness and b-wave amplitude were the primary outcome measures.
Main Results:
- Central macular thickness decreased significantly after oxygen therapy (P < 0.001).
- B-wave amplitude in electroretinography increased by 16% post-therapy (P < 0.001).
- Over 50% of eyes showed significant improvements in both structural and functional parameters.
Conclusions:
- Systemic oxygen therapy demonstrates potential benefits for diabetic macular ischemia.
- The therapy may reduce macular edema and enhance retinal electrophysiologic function.
- Further research is warranted to confirm these findings and explore therapeutic applications.
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