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Updated: Jun 4, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
[Malignant degeneration in laryngeal papillomatosis]
Ann-Luise Klinkby Grøn1, Joyce Horsmans Schultz, Jørn Abildgaard
1Øre-næse-hals-afdelingen, Vejle Sygehus, 7100 Vejle, Denmark.
Abstract:
Recurrent respiratory papillomatosis (RRP) is considered a benign disease although malignant transformation is well-described. The involvement of human papilloma virus (HPV) in malignant transformation is still being discussed. We present a case of rapid malignant transformation of RRP in a 29-year-old male. The tumour as well as biopsies from his previous laryngeal papillomas tested positive for HPV 16. Introduction of a quadrivalent HPV vaccine with a view to preventing cervical cancer may also reduce RRP, and subsequently possibly also the incidence of head-and-neck cancers.
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