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Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
Published on: September 22, 2017
Misalignments in the retinal nerve fiber layer evaluation using cirrus high-definition optical coherence tomography
Javier Moreno-Montañés1, Alfonso Antón, Natalia Olmo
1Department of Ophthalmology, Clínica Universidad de Navarra, Pamplona, Spain. jmoreno@unav.es
Journal of Glaucoma
|February 22, 2011
Summary
Complete misalignments (CMAs) affect about 30% of retinal nerve fiber layer (RNFL) scans and are linked to older age. RNFL thickness measurements remain reliable even with CMAs present.
Area of Science:
- Ophthalmology
- Medical Imaging
- Glaucoma Research
Background:
- Spectral-domain optical coherence tomography (SD-OCT) is crucial for retinal nerve fiber layer (RNFL) analysis.
- Misalignments (MAs) can affect the accuracy of RNFL measurements.
- Understanding MA characteristics is vital for reliable glaucoma diagnosis.
Purpose of the Study:
- To determine the frequency and characteristics of misalignments (MAs) in Cirrus SD-OCT RNFL analysis.
- To identify factors associated with MAs, particularly complete misalignments (CMAs).
- To assess the impact of CMAs on RNFL thickness measurements.
Main Methods:
- Cross-sectional study of 300 eyes (162 normal, 138 glaucomatous).
- Classification of MAs as limited or complete (CMA).
- Analysis of 153 repeated scans to compare RNFL thickness with and without CMAs.
Main Results:
- Limited MAs found in 46.7% of eyes; CMAs in 30.3%.
- CMA frequency and number correlated with older age.
- CMAs occurred more often in horizontal meridians and quadrants; no significant difference in RNFL thickness between scans with/without CMAs.
Conclusions:
- CMAs are common (approx. 30%) and associated with older age.
- RNFL thickness is not significantly affected by CMAs in the same patient.
- Scans with CMAs, especially within the measurement ring, can still be valuable for RNFL evaluation.
