[Changes of redox processes in liver under pv-88 at experimental hemorrhagic shock]

PV-88 is the Ca2+ L channel blocker from pyrrole compounds, that has been used at hemorrhagic shock - HS (model of Shock was created by the method of (Wiggers-Feine) on 60th minute (intravenous administration, 3 mg/kg). Mean arterial pressure was 40 mmHg. Effects were studied on 80th minute after blood letting. Blood was exfused 40 ml/kg. Effect of PV-88 on redox processes in liver was studied. Experiments were carried out on male cats. Right lobe of the liver and the metabolic indices: ATP, CO, NAD, NADP, ALP, SDH, LDH were studied with the use of histochemistry (Pearse). Investigations have shown that on 80th minute after PV-88 administration CO (p<0.05), NADP (p<0.05), ALP (p<0.001), SDH (p<0.05), and LDH (p>0.05) were increased, while ATP (p<0.001) and NAD (p<0.001) were decreased. Increase in LDH was not statistically significant. According to the results of investigations, after administration of PV-88 at HS 60 on 80th minute, in liver increases oxygen concentration and aerobic process respectively.