Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Brain stimulation.

R F Young1

  • 1Division of Neurological Surgery, University of California, Irvine Medical Center, Orange.

Neurosurgery Clinics of North America
|October 1, 1990
PubMed
Summary
This summary is machine-generated.

Brain stimulation offers significant pain relief for chronic pain patients, particularly those unresponsive to other treatments. While generally safe, effectiveness varies, prompting research into new targets for broader pain management.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genomic and Biochemical Characterization of Acinetobacter Podophage Petty Reveals a Novel Lysis Mechanism and Tail-Associated Depolymerase Activity.

Journal of virology·2018
Same author

Principles of community mental health in a rural setting: The Halifax County program.

Community mental health journal·2013
Same author

Chemical fingerprinting of naphthenic acids and oil sands process waters-A review of analytical methods for environmental samples.

Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering·2013
Same author

A clinical review of cancer of the breast and antecedent chronic conditions.

Edinburgh medical journal·2010
Same author

HEREDITARY POLYDACTYLISM.

British medical journal·2010
Same author

Reflections on the evolution of surgical technique.

Surgo; Glasgow University medical journal·2010
Same journal

Intramedullary Spinal Cord Tumors.

Neurosurgery clinics of North America·2026
Same journal

Spinal Cord Deformities Associated with Intramedullary Spinal Cord Tumors.

Neurosurgery clinics of North America·2026
Same journal

Radiation Therapy for Spinal Cord Tumors.

Neurosurgery clinics of North America·2026
Same journal

Treatment Strategies of Intramedullary Spinal Cord Tumors.

Neurosurgery clinics of North America·2026
Same journal

Vascular Lesions of the Spinal Cord: Arteriovenous and Cavernous Malformations.

Neurosurgery clinics of North America·2026
Same journal

Hemangioblastomas of the Spinal Cord.

Neurosurgery clinics of North America·2026
See all related articles

Area of Science:

  • Neuroscience
  • Pain Management
  • Neurosurgery

Background:

  • Electrical stimulation of the periaqueductal gray (PAG) induces analgesia via endogenous opioids.
  • Thalamic VPL/VPM stimulation inhibits spinal dorsal horn neurons, offering pain relief.

Purpose of the Study:

  • To evaluate the efficacy and safety of brain stimulation for chronic pain management.
  • To explore alternative stimulation targets for improved patient outcomes.

Main Methods:

  • Stereotactic implantation of stimulating electrodes under local anesthesia.
  • Acute and chronic electrical stimulation of brain targets like PAG and thalamic nuclei.
  • Exploration of new targets such as the K-F nucleus.

Main Results:

Related Experiment Videos

  • Acute thalamic stimulation relieves chronic pain in ~80% of patients.
  • Chronic stimulation yields 70% relief for peripheral/nociceptive pain, 50% for central pain.
  • Transient complications (15-25%) and permanent complications (1-2%) were reported.

Conclusions:

  • Brain stimulation is a viable option for refractory chronic pain, offering reasonable safety and efficacy.
  • Patient response varies, necessitating ongoing research into novel stimulation targets and improved hardware for enhanced pain relief.