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Related Concept Videos

MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
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Multiple regression assesses a linear relationship between one response or dependent variable and two or more independent variables. It has many practical applications.
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Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma
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[MicroRNA and multiple myeloma].

Chun-Ming Li1, Li-Juan Chen, Jian-Yong Li

  • 1Department of Hematology, Nanjing Medical University First Hospital, Nanjing 210029, Jiangsu Province, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|March 3, 2011
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) are small RNA molecules regulating gene expression. Their dysregulation is linked to multiple myeloma, abnormal chromosomes, and drug resistance, highlighting their role in cancer development.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Context:

  • MicroRNAs (miRNAs) are endogenous, non-coding small RNA molecules.
  • miRNAs function as gene regulators at the post-transcriptional level.
  • They bind to the 3'-untranslated region of target mRNAs to repress gene expression.

Purpose:

  • To review the characteristics and functions of miRNAs.
  • To explore the role of miRNAs in the development of multiple myeloma.
  • To investigate the involvement of miRNAs in abnormal karyotypes and drug resistance.

Summary:

  • This review covers miRNA characteristics, gene regulatory functions, and their involvement in cellular processes like proliferation, metabolism, apoptosis, and differentiation.
  • It highlights how miRNA dysregulation contributes to tumorigenesis.
  • Specific focus is given to the role of miRNAs in multiple myeloma, chromosomal abnormalities, and acquired drug resistance.

Impact:

  • Provides a comprehensive overview of miRNA research.
  • Enhances understanding of miRNA's role in multiple myeloma pathogenesis.
  • Offers insights into potential therapeutic targets for drug-resistant cancers.