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Related Concept Videos

Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...

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Related Experiment Video

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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

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Published on: July 28, 2013

Diffusion Tensor Imaging in Preclinical Huntington's Disease.

Vincent A Magnotta1, Jinsuh Kim, Tim Koscik

  • 1Department of Radiology, The University of Iowa, Iowa City, IA 52245.

Brain Imaging and Behavior
|September 28, 2011
PubMed
Summary
This summary is machine-generated.

Diffusion tensor imaging (DTI) may detect early white matter changes in preclinical Huntington's Disease (HD) gene carriers. These DTI measures show potential as biomarkers for disease progression before motor symptoms appear.

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Last Updated: Jun 3, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

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Published on: July 28, 2013

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

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Published on: August 14, 2019

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI&#8212;Application in Premanifest Huntington's Disease
09:06

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Published on: June 9, 2018

Area of Science:

  • Neuroimaging
  • Neurology
  • Biomarker Discovery

Background:

  • Huntington's Disease (HD) is a neurodegenerative disorder.
  • Early detection of HD progression is crucial for therapeutic interventions.
  • Preclinical stages of HD involve subtle brain changes before motor symptom onset.

Purpose of the Study:

  • To investigate white matter changes in preclinical Huntington's Disease gene carriers using diffusion tensor imaging (DTI).
  • To assess the potential of DTI-derived scalar maps as early biomarkers for HD progression.

Main Methods:

  • Cross-sectional diffusion tensor imaging and anatomical brain imaging were performed on 31 preclinical HD gene mutation carriers.
  • Fractional anisotropy (FA) scalar maps were generated and correlated with the estimated five-year probability of diagnosis.
  • Analysis focused on correlations within specific brain regions like the putamen and external capsule.

Main Results:

  • A positive correlation between FA maps and the probability of HD diagnosis was observed in the putamen.
  • A negative correlation was found between FA maps and the probability of HD diagnosis in the external capsule.
  • These findings indicate that DTI measures reflect early disease-related changes in white matter.

Conclusions:

  • Scalar maps from DTI are associated with the earliest stages of Huntington's Disease progression, even before clinical diagnosis.
  • DTI measures demonstrate potential as reliable biomarkers for tracking disease progression in pre-manifest HD subjects.
  • This supports the use of DTI in clinical trials for evaluating therapeutic efficacy in early-stage HD.