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[Thrombotic risk in assisted reproductive technology].
Adriano Alatri1, Bruno Tribout, Baris Gencer
1Service d'angiologie, CHUV, 1011 Lausanne. adriano.alatri@chuv.ch
Revue Medicale Suisse
|March 22, 2011
Summary
Assisted reproductive technology (ART) increases risks of blood clots, particularly with ovarian hyperstimulation syndrome (OHSS). Assess and manage thromboembolic risk in high-risk patients undergoing ART and OHSS.
Area of Science:
- Reproductive endocrinology and thrombosis research.
Context:
- Assisted reproductive technology (ART) use is rising globally.
- Thromboembolic events occur in 0.1% of ART cycles, often linked to ovarian hyperstimulation syndrome (OHSS).
Purpose:
- To clarify the mechanisms linking OHSS and ART hormonal stimulation to thromboembolic events.
- To recommend risk assessment and thromboprophylaxis strategies for ART patients.
Summary:
- OHSS and ART hormonal stimulation create a prothrombotic state via vascular endothelial growth factor, high estradiol, and blood hyperviscosity.
- Individual thromboembolic risk assessment is crucial before ART.
- Thromboprophylaxis is recommended for high-risk patients and those with moderate-to-severe OHSS.
Impact:
- Informs clinical practice regarding thromboembolic risk management in ART.
- Highlights the need for proactive patient assessment and preventative measures.
- Contributes to improving ART safety by addressing a significant complication.
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