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Updated: Jun 3, 2026
10:26
Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
Genetic predisposition to persistent apical periodontitis
Jussara M Morsani1, Anita Aminoshariae, Yiping Weng Han
1American Board of Endodontics, Case Western Reserve School of Dental Medicine, Cleveland, Ohio, USA.
Journal of Endodontics
|March 23, 2011
Summary
Genetic variations in interleukin-1 beta (IL-1β) are linked to endodontic failure. Specifically, allele2 of IL-1β increases susceptibility to persistent apical periodontitis (PAP) after root canal therapy.
Area of Science:
- Endodontology
- Immunogenetics
- Oral Biology
Background:
- Interleukin-1 (IL-1) is a proinflammatory cytokine crucial for host defense and bone metabolism.
- Allele2 of IL-1β is associated with a fourfold increase in IL-1β production.
- Persistent apical periodontitis (PAP) can occur after root canal therapy (RCT).
Purpose of the Study:
- To investigate the role of IL-1β gene polymorphism in the pathogenesis of endodontic failure.
- To determine if the IL-1β gene polymorphism (allele2) influences host response and predisposes to PAP.
Main Methods:
- A case-control study design was employed.
- 34 subjects with PAP and 61 healthy controls were recruited.
- IL-1β gene polymorphism was analyzed using polymerase chain reaction and restriction fragment length polymorphism.
Main Results:
- A significant difference in genotype distribution was observed between cases (70.6%) and controls (24.6%) (P < .001).
- The polymorphic genotype associated with increased IL-1β production was more prevalent in patients with PAP.
Conclusions:
- Specific genetic markers for elevated IL-1β production may increase susceptibility to persistent apical periodontitis.
- IL-1β gene polymorphism is implicated in the pathogenesis of endodontic failure.
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