A Monte Carlo analysis of peritoneal antimicrobial pharmacokinetics
Sanjukta Hota1, Philip Crooke, John Hotchkiss
1Department of Mathematics, Fisk University, Nashville, TN 37208, USA. sanjuktahota@gmail.com
Abstract:
Peritoneal dialysis-associated peritonitis (PDAP) can be treated using very different regimens of antimicrobial administration, regimens that result in different pharmacokinetic outcomes and systemic exposure levels. Currently, there is no population-level pharmacokinetic framework germane to the treatment of PDAP. We coupled a differential-equation-based model of antimicrobial kinetics to a Monte Carlo simulation framework, and conducted "in silico" clinical trials to explore the anticipated effects of different antimicrobial dosing regimens on relevant pharmacokinetic parameters (AUC/MIC and time greater than 5 ×MIC) and the level of systemic exposure.
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