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Updated: Jun 3, 2026
12:37
Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
[Melanotan-induced lentigines and nevi]
Kristian Thestrup-Pedersen1, Knud Søndergaard
1Hudklinikken, 4800 Nykøbing Falster, Denmark. ktp56@hotmail.com
Ugeskrift for Laeger
|April 2, 2011
Summary
Self-injecting melanotan significantly increased skin pigmentation. This peptide also caused new moles and dark spots to appear, including on the genitals, though no malignancy was detected.
Area of Science:
- Dermatology
- Endocrinology
- Pharmacology
Background:
- Melanotan is a synthetic peptide hormone analog of alpha-melanocyte-stimulating hormone.
- It is used for increasing skin pigmentation and has potential applications in treating certain skin conditions.
- Self-administration of unapproved substances carries inherent risks.
Observation:
- A 25-year-old male self-administered over 150 doses of melanotan.
- Significant increase in skin pigmentation was noted.
- Development of new nevi and lentigines, with darkening of existing nevi, including on the genitals.
Findings:
- Histopathological examination of excised nevi revealed no signs of malignant transformation.
- The observed dermatological changes are associated with melanotan use.
Implications:
- This case highlights the potential dermatological side effects of melanotan misuse.
- Further research is needed to understand the long-term effects and safety profile of melanotan.
- Clinical vigilance for melanotan-induced skin changes is warranted.
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