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Related Concept Videos

Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Psychosurgery01:30

Psychosurgery

Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...

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Generation of Induced Pluripotent Stem Cells from Frozen Buffy Coats using Non-integrating Episomal Plasmids
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iPSCs: induced back to controversy.

Athanasia D Panopoulos1, Sergio Ruiz, Juan Carlos Izpisua Belmonte

  • 1Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines, La Jolla, CA 92037, USA.

Cell Stem Cell
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Summary
This summary is machine-generated.

Recent studies reveal genetic and epigenetic changes in induced pluripotent stem cells (iPSCs). These findings raise questions about the future therapeutic applications of iPSCs and their potential impact.

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Area of Science:

  • Stem Cell Biology
  • Epigenetics
  • Genetics

Background:

  • Recent reports highlight significant genetic and epigenetic alterations in induced pluripotent stem cells (iPSCs).
  • These discoveries stem from multiple independent research groups, underscoring the consistency of the findings.
  • The alterations observed raise critical questions regarding the stability and safety of iPSCs.

Discussion:

  • The implications of these genetic and epigenetic changes for the future of iPSC technology are under intense scientific debate.
  • Understanding these alterations is crucial for assessing the true potential and limitations of iPSCs in regenerative medicine.
  • The findings challenge the assumption of complete reprogramming and genomic stability in iPSCs.

Key Insights:

  • Genetic and epigenetic modifications are recurrent features of iPSCs.
  • These alterations may impact the functional characteristics and long-term behavior of iPSCs.
  • The clinical utility of iPSCs may be constrained by these observed changes.

Outlook:

  • Further research is essential to elucidate the functional consequences of iPSC genetic and epigenetic alterations.
  • Developing robust methods to control or correct these alterations will be critical for therapeutic applications.
  • The field must address these findings to fully realize the promise of iPSC-based therapies.