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Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
Imaging of mesothelioma
1Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA. rgill@partners.org
Abstract:
Malignant pleural mesothelioma (MPM) is an asbestos-related neoplasm that originates in pleural mesothelial cells and progresses locally along the pleura until it encases the lungs and mediastinum, ultimately causing death. Imaging plays a crucial role in diagnosis and optimal management. Computed tomography (CT) continues to be the primary and initial imaging modality. Magnetic resonance imaging (MRI) complements CT scan and is superior in determining chest wall and diaphragmatic invasion. FDG18-PET/CT provides anatamo-metabolic information and is superior to both CT and MRI in overall staging and monitoring response to therapy. This chapter will detail the imaging finding of MPM and role of imaging in guiding management.
Insights
Malignant pleural mesothelioma (MPM), an asbestos-related cancer, requires advanced imaging for diagnosis and management. This review details how CT, MRI, and PET/CT scans aid in staging and treatment monitoring for this aggressive neoplasm.
Area of Science:
- Oncology
- Radiology
- Medical Imaging
Background:
- Malignant pleural mesothelioma (MPM) is a rare but aggressive cancer linked to asbestos exposure.
- It originates in the pleura, progressively encasing the lungs and mediastinum.
- Accurate diagnosis and staging are critical for effective patient management.
Purpose of the Study:
- To review the critical role of various imaging modalities in the diagnosis and management of MPM.
- To highlight the strengths and weaknesses of different imaging techniques for MPM.
- To guide the use of imaging in staging and monitoring treatment response.
Main Methods:
- Computed Tomography (CT) as the primary initial imaging modality.
- Magnetic Resonance Imaging (MRI) for detailed assessment of chest wall and diaphragmatic invasion.
- FDG-PET/CT for integrated anatomical and metabolic staging and therapy response monitoring.
Main Results:
- CT is essential for initial MPM detection and assessment.
- MRI offers superior soft tissue contrast for evaluating local invasion.
- FDG-PET/CT provides comprehensive staging and is valuable for tracking treatment efficacy.
Conclusions:
- A multi-modal imaging approach is crucial for optimal MPM management.
- Imaging guides therapeutic decisions and assesses treatment effectiveness.
- Understanding imaging findings is key to improving outcomes for patients with MPM.
