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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis of new 1-phenyl-6H-pyrido[4,3-b]carbazole derivatives with potential cytostatic activity
Beata Tylińska1, Ryszard Jasztold-Howorko, Henryk Mastalarz
1Wrocław Medical University, Faculty of Pharmacy, Department of Organic Chemistry, Grodzka 9 St., 50-137 Wrocław, Poland. diana@chorg.am.wroc.pl
Abstract:
A number of new 1-substituted-6H-pyrido[4,3-b]carbazole derivatives have been synthesized. Nine of the newly obtained compounds were subjected to preliminary in vitro cytostatic activity screening against murine leukemia (L1210), human lung cancer (A549) and human colon cancer (HT29) cell lines. One particular compound 6f exhibited over 20 times better activity against L1210 tumor cell line than the reference ellipticine.

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